Music Effects on Cognitive Function of the Elderly

Whether the music is orchestral, rock, country, or jazz, most seniors like to listen to some kind of music. Music can soothe or energize, make us happy or sad, but the kind we like to hear does something that can be positively reinforcing or otherwise we would not listen to it. As my 80-year-old jazz trumpeter friend, Richard Phelps, recently said at his birthday party, "Where there is life there is music. Where there is music, there is life."

Relatively little research has been done on the effects of music on brain function in older people. But one study recently reported the effects in older adults of background music on brain processing speed and two kinds of memory (episodic and semantic). The subjects were not musicians and had an average age of 69 years.

The music test conditions were: 1) no music control, 2) white noise control, 3) a Mozart recording, and 4) a Mahler recording. All 65 subjects were tested in counter-balanced order in all four categories. The music was played at modest volume as background before and during performance of the cognitive tasks, a mental processing speed task and the two memory tasks. The episodic memory task involved trying to recall a list of 15 words immediately after a two-minute study period. The semantic memory task involved word fluency in which subjects wrote as many words as they could think of beginning with three letters of the alphabet.

Processing speed performance was faster while listening to Mozart than with the Mahler or white noise conditions. No improvement in the Mahler condition was seen over white noise or no music.

Episodic memory performance was better when listening to either type of music thatn while hearing white noise or no music. No difference was noted between the two types of music.

Semantic memory was better for both kinds of music than with white noise and better with Mozart that with no music.

Recognizing that emotions could be a relevant factor, the experimenters analyzed a mood questionnaire comparing the two music conditions with white noise. Mozart generated higher happiness indicators than did Mahler or white noise. Mahler was rated more sad than Mozart and comparable to white noise.

Thus, happy, but not sad, music correlated with increased processing speed. The researchers speculated that happy subjects were more around and alert.

Surprisingly, both happy and sad music enhanced both kinds of memory over the white noise or silence condition. But it is not clear if this observation is generally applicable. The authors did mention without emphasis that the both kinds of music were instrumental and lacked loudness or lyrics that could have been distracting and thus impair memory. I think this point is substantial. When lyrics are present, the brain is dragged into trying to hear the words and thinking about their meaning. These thought processes would surely interfere with trying to memorize new information or recall previous learned material.

A point not considered at all is personal preference for a certain types of music. There are people who don't like classical music, and the data in this study could have been made "noisy" if enough of the 65 people disliked classical music and were actually distracted by it. In other words, the effects noted in this study might have been magnified if the subjects were allowed to hear their preferred music.

My take-home lesson was actually formed over five decades ago when I listed to jazz records while plowing my way through memorizing a veterinary medical curriculum. Then, I thought that the benefit was stress reduction (veterinary school IS stressful and happy jazz certainly reduces stress). Now perhaps I see that frequent listening to music that was pleasurable for me might have actually helped my memory capability. If you still have doubts you might want to check my latest blog post, "Happy thoughts can make you more competent" (http://thankyoubrain.blogspot.com/2015/01/happy-thoughts-can-make-you-more.html).

Anyway, now that I am in the elderly category, I see there is still reason to listen to the music I like. Music can be therapy for old age.

“People haven't always been there for me but music always has.”

    —Taylor Swift

"Memory Medic's" latest book is "Improve Your Memory for a Healthy Brain. Memory Is the Canary in Your Brain's Coal Mine." It is available in inexpensive e-book form at Amazon or in all formats at Smashwords.com.

Source:

Bottiroli, Sara et al. (2014). The cognitive effects of listening to background music on older adults: processing speed improves with upbeat music, while memory seems to benefit from both upbeat and downbeat music. Frontiers in Aging Neuroscience. Oct. 15. doi: 10.3389/fnagi.2014.00284.

Aging memory system

Working memory is the dynamic extension of primary memory. It is the ‘system that performs the task of temporarily manipulating information’.

Oder adults perform more poorly that their younger counterparts on tasks assess the combined processing and storage capacity of working memory, and these age-related working memory span differences account for a significant proportion of the age-related variance on written and spoken language comprehension tasks.

There is overwhelming evidence that normal adult aging is accompanied by a working memory deficit.  Aging is a natural process that must be studied intensively, for it to remains of one of the agonizing problems in all biology.

Interestingly, while aging is associated with significant declines in memory, the brain structures associated with encoding and memory show minimal age related volumetric declines. In this case the older adults fail to use spontaneously specific encoding and retrieving strategies.

Nonetheless, older adults can successfully acquire and apply strategies for the considering and retrieval of new information, of taught to do so.
Aging memory system

Health Benefits of Resveratrol: New Plaudits

Joe: My doctor told me to give up drinking, smoking, and fatty foods.

Sam: What will you do?

Joe: I think I’ll give up my doctor.

I try not to get too excited about memory benefits of supplements, because too often the claims are not substantiated by studies that are well controlled and peer reviewed. I now think resveratrol may be one of the few supplements that benefits brain function.

When I wrote my first blog on research on resveratrol benefits for brain function and memory, there were over 2,000 scientific papers.[1]Don't worry; I am only going to tell you about a few studies.

Resveratrol is an active ingredient in red wine. This compound has been credited for explaining why red-wine drinkers in France, who drink more wine than most people, are healthier than would be predicted by their lifestyle of little exercise and eating lots of cheese. The problem is most studies suggest you would have to drink a 100 or more glasses of red wine a day to get much resveratrol effect (and that effect would obviously be negated by a toxic dose of alcohol). An obviously more healthful choice is the highly concentrated pill forms of resveratrol that are now on the market.

Most of the protective biological actions associated with resveratrol have been associated with its scavenger properties for free radicals and the protective effects that it confers on the heart and diabetes. 

One important study comes from a diabetes research group in Brazil recently who reported a beneficial effect of resveratrol on diabetic rats.[2]Resveratrol (in a modest rat dose of 10 and 20 mg per kilogram per day for 30 days) prevented the impairment of memory induced by diabetes. An earlier study by another group showed resveratrol improved glucose metabolism and promoted longevity in diabetic mice.

Another benefit of resveratrol is the anti-oxidant property. The brain produces more free-radical damage than other organs, and compared with other organs the brain has especially low levels of antioxidant defense enzymes. 

One recent study has revealed resveratrol had protective effects against brain damage caused by a chemical that kills acetylcholine neurons. Injection of this toxin into the brain of rats impaired their memory performance in two kinds of maze tasks. The impairment was significantly reduced by repeated injection of resveratrol (10 and 20 mg/kg) per day for 25 days, beginning four days before the toxin injection.[3]

Another recent study examined effects on working memory in mice fed a resveratrol-supplemented diet for four weeks before being injected with a cytokine to induce inflammation and accelerate aging. Resveratrol significantly reduced memory impairment in the aged group, but not in the young adults[4]. The lack of benefit in young adults was a little misleading, in that there was a "ceiling effect" in that the young adults were not impaired by the cytokine injection.

 The practical issue for us is whether resveratrol will help cognitive function in humans, especially healthy humans. It seems likely because other substances that have strong anti-oxidant properties seem to improve memory capability. Because animal studies have shown promise for resveratrol in preventing or treatment several different conditions associated with aging, several human clinical trials have been initiated.[5]

 An impressive new study of older humans, male and female, has just been reported.[6]Twenty-three healthy, but overweight people completed 6 months of daily resveratrol intake (200 mg ― the commercial brand I take has 300 mg/capsule). A paired control group got placebo pills. A double-blind design assured that neither the subjects nor the experimenters knew which individuals were in each group during data processing.

Memory tests of word recall revealed significant improvement in the resveratrol group. Resveratrol also increased brain-scan measures of functional connectivity, which identified  linked neural activity between the hippocampus and several areas of cerebral cortex.

Because others had shown that resveratrol increased insulin sensitivity in humans, these authors examine several markers important to diabetes. Resveratrol decreased the standing levels of sugar-bound hemoglobin, a standard marker for glucose control.  

What foods besides red grapes have resveratrol? The most likely other sources you would eat or drink are blueberries, cranberries, and peanuts. It is not likely that you could drink or eat enough of such substances to get enough resveratrol to do much good. Because of the scientifically documented benefits of resveratrol, highly concentrated supplements are now on the market (I have been taking it for a couple of years) I haven't given up my two glasses of red wine each day, but I have started taking one of the supplements. I haven't seen any reports that high doses of resveratrol are toxic.

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[1] http://thankyoubrain.blogspot.com/2010/04/resveratrol-red-wine-magic-chemical.htmlApril 4, 2010.

[2] Schmatz R, et al. (2009). Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2009 May 21;610(1-3):42-8. Epub 2009 Mar 19.

[3] Kumar, A. et al. 2007. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology.79 (1): 17-26. DOI: 10.1159/000097511

[4] Abraham, J., and Johnson, R. W. 2009. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation research. 12 (6): 445-453.  DOI: 10.1089/rej.2009.0888

[5]Smoliga, J. M. et al. (2011). Resveratrol and health – a comprehensive review of human clinical trials. Mol. Nutrition Food Res. 55: 1129-1141

[6] Witte, A. V., et al. (2014) Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neuroscience. 34 23): 7862-7870.